Epidermal growth factor receptor kinase translocation and activation in vivo.
نویسندگان
چکیده
منابع مشابه
Noninvasive imaging and quantification of epidermal growth factor receptor kinase activation in vivo.
Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) critical in tumor growth and a major target for anticancer drug development. However, thus far, there is no effective system to monitor its activities in vivo. Here, we report a novel approach to monitor EGFR activation based on the bifragment luciferase reconstitution system. The EGFR receptor and its interacting partn...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1986
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)83935-2